Fecal microbial transplants (FMTs) have been practiced since the 4th Century but gained FDA approval for C.diff treatment in 2013. Recent studies indicate potential risks with FMT, revealing that mismatches between donor fecal matter and the recipient's gut can lead to significant changes in the microbiome, possibly causing new health issues. While FMTs are also being considered for conditions like Crohn's disease and ulcerative colitis, caution is warranted as even a single transplant can affect immune and metabolic functions.
"Even a single FMT will cause a change in the host-microbe relationships in these very different regions of the bowel that may be very difficult to reverse."
"Fecal microbial transplants (FMTs) have been hailed as a treatment for Clostridium difficile; however, mismatched donor fecal matter may introduce health risks."
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