The article discusses the significance of one-carbon homologs, which are structurally related compounds differing by a single methylene unit, in affecting the properties and functions of various organic molecules such as pharmaceuticals and agrochemicals. Despite existing homologation strategies, efficient methods for one-carbon chain extension in alkenes pose a challenge. The authors introduce a novel catalytic process that utilizes a multifaceted allyl-sulfone reagent, allowing for effective alkene chain elongation. This process yields new homologs of Cyclosporine-A with altered pharmacological properties, shining light on their potential as cyclophilin inhibitors.
One-carbon homologs, which vary in chain length by a methylene unit, significantly influence the function of various organic molecules, highlighting their importance in molecular discovery.
Efficient generation of one-carbon homologs in alkenes remains a synthetic challenge, yet recent advancements in catalysis and cross-metathesis methods have made strides in this area.
The innovative one-carbon homologation process reported utilizes an allyl-sulfone reagent to enhance alkene chain extension, revealing new homologs with potential biological applications.
These newly created homologs of Cyclosporine-A display altered pharmacological properties, representing a promising avenue for cyclophilin inhibitors in therapeutic development.
#one-carbon-homologs #synthetic-chemistry #molecular-discovery #alkene-homologation #pharmacological-properties
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