"A cardiovascular disease (CVD) risk prediction tool developed by Northwestern Medicine scientists may also be effective for identifying which patients would most benefit from statin therapy, according to a recent study published in JAMA Cardiology. The CVD risk calculator, called the PREVENT (Predicting Risk of cardiovascular disease EVENTs) risk equations, could ultimately help improve clinical decision-making conversations between patients and their physicians, according to Sadiya Khan, '09 MD, '14 MSc, '10, '12 GME, the Magerstadt Professor of Cardiovascular Epidemiology and lead author of the study."
""We hope these data will help support shared decision-making for starting a statin medicine. We want to help improve the conversation between healthcare clinicians and their patients about their risk and the potential benefit of starting a medication," said Khan, who is also an associate professor of Medical Social Sciences in the Division of Determinants of Health and of Preventive Medicine in the Division of Epidemiology. In 2023, Khan and colleagues developed the American Heart Association's PREVENT risk equations to more accurately estimate CVD risk. In doing so, they recognized a need for new risk thresholds for when to consider prescribing medications such as statins to lower a patient's risk of CVD."
The PREVENT risk equations estimate 10-year atherosclerotic cardiovascular disease (CVD) risk and may identify patients who would derive the greatest absolute benefit from statin therapy. A cross-sectional analysis of National Health and Nutrition Examination Survey data compared population-level statin eligibility when applying PREVENT-based 10-year risk estimates versus guideline-defined thresholds from the Pooled Cohort Equations (PCE). PREVENT thresholds were evaluated against prior PCE thresholds to assess differences in estimated risk and resultant changes in statin eligibility. PREVENT offers more tailored risk estimates that could inform shared decision-making and potentially alter recommendations for initiating statin medication.
#cardiovascular-risk-prediction #prevent-risk-equations #statin-eligibility #pooled-cohort-equations
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