"The drops contain pilocarpine, "a drug that constricts the pupils and contracts the ciliary muscle, which is a muscle controlling the eye's accommodation for seeing objects at varying distances," as well as the ingredient diclofenac, "a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation and the discomfort that pilocarpine often causes." Participants received one of three doses of the medication, with varying concentrations of diclofenac (1%, 2%, and 3%). Most participants, who suffered from farsightedness, could read two to three additional lines on the Jaeger eye chart used for testing sight after using the drops."
"Dr. Benozzi said, per Science Daily, that the way patients responded to the treatments depended on the severity of their condition. "Patients with less severe presbyopia responded best to 1% concentrations, while those with more advanced presbyopia required higher 2% or 3% concentrations to achieve significant visual improvement." Still, the drops improved sight, not just for short-range vision, but at all distances. "Our most significant result showed rapid and sustained improvements in near vision for all three concentrations," Benozzi said."
A treatment using pilocarpine combined with diclofenac produced measurable vision improvements for 766 patients with presbyopia, average age 55. The formulation uses pilocarpine to constrict pupils and contract the ciliary muscle, and diclofenac to reduce inflammation and pilocarpine-related discomfort. Patients received one of three diclofenac concentrations (1%, 2%, 3%), and those with milder presbyopia responded best to 1% while more advanced cases required 2% or 3% for significant gains. Most participants read two to three additional Jaeger chart lines, and improvements extended across near and distance vision with rapid and sustained near-vision benefits.
Read at Fast Company
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