#late-stage-functionalization

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#n-nitroamines #deaminative-functionalization #aryl-cn-bond-activation #ch-oxidation #-unsaturated-carbonyl
Science
fromNature
1 week ago

Direct deaminative functionalization with N-nitroamines - Nature

Direct deamination via N-nitroamines converts aromatic C−N bonds into diverse C−X and C−C bonds, providing a general, safer alternative to diazonium-based methods.
Science
fromNature
2 weeks ago

Selective Methylene Oxidation in ,-Unsaturated Carbonyl Natural Products - Nature

Replacing carboxylic acid with an H-bond donor solvent in manganese PDP catalysts shifts the oxidant to favor electron-rich methylene oxidation while suppressing epoxidation.
fromNature
2 weeks ago

Photocatalytic oxygen-atom transmutation of oxetanes - Nature

The replacement of oxygen atoms in readily available oxetanes would offer a direct route to a variety of these cyclic pharmacophores, yet such atom swapping has been rarely reported for non-aromatic molecules. Here we report a general photocatalytic strategy that selectively substitutes the oxygen atom of an oxetane with a nitrogen-, sulfur- or carbon-based moiety, transforming it into a diverse range of saturated cyclic building blocks in a single operation.
Science
fromwww.nature.com
2 weeks ago

Deaminative cross-coupling of amines by boryl radical -scission

Native primary, secondary, and tertiary amines can be activated via borane coordination to generate boryl radicals for copper-catalyzed deaminative cross-coupling.
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