The majority of brain diseases need new therapies, as current small molecules often lack selectivity, leading to side effects. Antibodies, while specific, have limited brain penetration.
We know that exercise does so many good things to the brain and against Alzheimer's disease... we actually want to activate these molecular pathways using pharmacology.
The study shows that conventional dendritic cells (DCs) are critical for T cell responses against tumors, underscoring the need for effective DC migration to lymph nodes.