When you design your home with intentionality, you are essentially 'hard-coding' healthy behaviors into your daily rhythm. Health outcomes are the result of thousands of micro-decisions—so in his own home, he prioritized spaces like the kitchen, whose open layout makes cooking a pleasure, and the gym, centrally located.
I am running. Ahead lie endless mangrove swamps, behind the green-blue waters of the Caribbean. My mind is rising away from my lurching body, which is on a treadmill and attached to a beeping machine by wires and tubes. Nurses circle. The gradient increases, as does the speed. Dignity slips away as my body fights for breath. They're after my "VO2 max", the amount of oxygen my body can absorb during my maximum capacity for exercise.
Running the company is no easy feat: Marchione works seven days a week, putting in more than 12 hours a day. That means his self-care routine is precisely dialed in. Marchione says he has always taken an unconventional, even contrarian approach, exploring beyond what mainstream medicine recommends. As a teen, he was an early adopter of fitness wearables like the Oura ring, and got into blue-light-blocking glasses and mouth taping - trends that, despite some mixed evidence, have become incredibly popular in wellness today.
"There's a potential for psychedelics to play a more important role in all of our lives, and wouldn't it be amazing if it was also a longevity therapy," Johnson proclaimed on the stream. Prior to consuming the shrooms Sunday-which has been legal at licensed facilities in Oregon since 2023-Johnson measured his brain activity with a $50,000 helmet produced by Kernel, a neuroimaging company founded by the 48-year-old. He also took saliva samples and temperature readings.
Concern for physical and mental well-being conjured up images of mothers doing aerobics with Jane Fonda, or of influencers drinking kale and chia smoothies. Dieting was something women did. Men were more likely to talk about how much they drank, rather than how little they ate. It's not that men don't need to take care of themselves: men have a shorter life expectancy, they drink more alcohol, they have a poorer diet, and their mental health problems more frequently end in suicide.
Vibe coding, an emerging software development that turns natural language into computer code using artificial intelligence, has been named Collins dictionary's word of the year for 2025. Lexicographers at Collins monitor the 24bn-word Collins Corpus, which draws from a range of media sources, including social media, to create the annual list of new and notable words that reflect our ever-evolving language. They chose vibe coding as word of the year after observing a huge increase in usage since its first appearance in February.
Every day, I shift between strategy and execution, guiding a team that depends on me to make clear decisions. The constant pressure takes its toll. Stress lingers, energy dips at the wrong moment, and brain fog has a way of showing up when clarity is most needed. I feel this even more with the added demands of being a working mom and hosting a podcast, where I have to be sharp, present and on my toes no matter what else is happening in my day.
I've been in the entrepreneurship game long enough to spot when something big is coming. And I'm telling you right now: I believe biohacking isn't just another wellness fad. It's a legitimate business strategy that's giving smart entrepreneurs a massive competitive edge. The numbers don't lie: why entrepreneurs need this now Eighty-seven percent of entrepreneurs deal with mental health issues versus just 48% of regular people. But here's the real kicker - it's not just stress. I think it's about trying to maintain peak performance while your body systematically breaks down under the demands of building something meaningful.
Going into the retreat, I knew I would be in the minority regarding my fitness level. What I didn't realize was that the other retreat attendees would predominantly be women. As a queer person, this is always a welcome surprise, but I found the discrepancy interesting. Do men not take a holistic approach to well-being in the same way women do?
Welcome to Dave Asprey's 2025 Biohacking Conference: a symposium of tech bros, wellness influencers, psychonauts, and scientists, all hoping to thwart the ravages of time with unorthodox—and often unproven—medical treatments.
